| 视神经横断后生长抑制因子Nogo及其受体NgR mRNA表达的变化及意义 |
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| 引用本文： | 尹小磊,叶剑,袁容娣,陈春林,郑政,霍妍,邹欢. 视神经横断后生长抑制因子Nogo及其受体NgR mRNA表达的变化及意义[J]. 标记免疫分析与临床, 2011, 18(5): 326-329 |
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| 作者姓名： | 尹小磊 叶剑 袁容娣 陈春林 郑政 霍妍 邹欢 |
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| 作者单位： | 1. 中国人民解放军第305医院眼科,北京,100017
2. 中国人民解放军第三军医大学大坪医院野战外科研究所眼科,重庆,400042 |
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| 基金项目： | 国家自然科学基金资助项目(No.31070968) |
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| 摘 要： | 观察大鼠视神经横断后Nogo-A及其受体NgR mRNA表达的变化.将36只正常成年SD大鼠随机分为三组,视神经横断7d组、14d组和正常对照组,每组12只.分别提取视神经组织,使用实时荧光定量聚合酶链式反应法定量分析Nogo-A及NgR mRNA表达量的变化.实验结果显示,在大鼠的视神经组织中存在Nogo-A及其受体...
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| 关 键 词： | 视神经 轴突横断术 大鼠 生长抑制因子 实时荧光定量聚合酶链式反应 |
Expression Changes of Nogo-A and NgR mRNA in Axotomic Optic Nerves |
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| YIN Xiao-lei,YE Jian,YUAN Rong-di,CHEN Chun-lin,ZHENG Zheng,HUO Yan,ZOU Huan. Expression Changes of Nogo-A and NgR mRNA in Axotomic Optic Nerves[J]. Labeled Immunoassays and Clinical Medicine, 2011, 18(5): 326-329 |
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| Authors: | YIN Xiao-lei YE Jian YUAN Rong-di CHEN Chun-lin ZHENG Zheng HUO Yan ZOU Huan |
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| Affiliation: | YIN Xiao-lei,YE Jian,YUAN Rong-di,CHEN Chun-lin,ZHENG Zheng,HUO Yan,ZOU Huan(Department of Ophthalmology,305 Hospital of PLA,Beijing 100017,China) |
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| Abstract: | To investigate the changes of Nogo-A and NgR mRNA expression in axotomic optic nerves of rat,36 adult normal SD rats were randomly divided into 3 groups: the normal control group,bilateral optic nerve transection treated 7 days later group and 14 days later group.There were 12 rats in each group.After tissue preparation,the mRNA levels were detected by real-time fluorescent quantitation polymerase chain reaction.The results showed that Nogo-A and NgR mRNA were expressed in the rat optic nerve.The level of t... |
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| Keywords: | Optic nerve Axotomy Rat Growth inhibitor Real-time fluorescent quantitation polymer-ase chain reaction |
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