| 尼可胺的致突变性研究 |
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| 引用本文： | 刘晓秋,韩英,沈秀,周则卫. 尼可胺的致突变性研究[J]. 癌变．畸变．突变, 2011, 23(5): 392-394. DOI: 10.3969/j.issn.1004-616x.2011.05.017 |
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| 作者姓名： | 刘晓秋 韩英 沈秀 周则卫 |
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| 作者单位： | 中国医学科学院北京协和医学院放射医学研究所,天津市分子核医学重点实验室,天津,300192 |
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| 基金项目： | 天津市科技支撑计划重点项目(09ZCKFSH01500) |
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| 摘 要： | 目的：研究尼可胺的致突变性,为临床安全用药提供理论依据。方法：采用Ames试验、小鼠微核试验及中国仓鼠肺细胞（CHL）染色体畸变试验检测尼可胺的致突变性。结果：Ames试验中在加和不加代谢活化系统（S9）的条件下,尼可胺各剂量组（每皿8、40、200、1000、5000μg）4种实验菌株的平均回变菌落数均在相应菌株自发回变数的2倍以内,且无剂量-反应关系。尼可胺各剂量组（400、200、100mg/kg）小鼠骨髓细胞微核率及CHL细胞染色体畸变率与阴性对照组比较,其差异均无统计学意义（P〉0.05）。结论：在本实验条件下,尼可胺无致突变作用。
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| 关 键 词： | Ames试验 微核试验 染色体畸变试验 尼可胺 |
Mutagencity study of NiKeAn |
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| LIU Xiao-qiu,HAN Ying,SHEN Xiu,ZHOU Ze-wei. Mutagencity study of NiKeAn[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2011, 23(5): 392-394. DOI: 10.3969/j.issn.1004-616x.2011.05.017 |
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| Authors: | LIU Xiao-qiu HAN Ying SHEN Xiu ZHOU Ze-wei |
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| Affiliation: | LIU Xiao-qiu,HAN Ying,SHEN Xiu,ZHOU Ze - wei (Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Peking Union Medical College,Tianjin 300192,China) |
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| Abstract: | OBJECTIVE:To study the genetic toxicity of NiKeAn.METHODS:the mutagenicity of NiKeAn was examined using Ames test,micronucleus test and CHL cell chromosome aberration test.RESULTS:No increase in the number of revertant colonies was found in the Ames test with and without S9 mixture.The micronucleus rates and chromosome aberration rates at all doses were not significantly different from the control group(P>0.05). CONCLUSION:Mutagenicity of NiKeAn was not observed in this study. |
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| Keywords: | Ames test micronucleus test chromosome aberration test NiKeAn |
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