| 束缚应激致大鼠心肌损伤的线粒体膜机制探讨 |
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| 引用本文： | 任会荣,钱令嘉,弓景波,王新兴,任崇余.束缚应激致大鼠心肌损伤的线粒体膜机制探讨[J].航天医学与医学工程,2003,16(1):32-35. |
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| 作者姓名： | 任会荣 钱令嘉 弓景波 王新兴 任崇余 |
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| 作者单位： | 卫生学环境医学研究所应激医学实验室,天津,300050 |
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| 基金项目： | 国家自然科学基金 (3 9970 63 5 )，国家重点基础研究发展规划资助项目 (G2 0 0 0 0 5 69) |
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| 摘 要： | 目的：观察束缚应激对大鼠心肌细胞线粒体膜生物学特性和功能的影响，探讨应激性心肌损伤的线粒体膜机制。方法：建立应激动物模型，分别束缚不同时间后处死所有大鼠，检测线粒体PTP开放程度、膜流动性的改变、膜脂质过氧化水平及线粒体呼吸功能变化。结果：束缚应激导致线粒体膜PTP开放、膜流动性降低、膜脂质过氧化生成增多及线粒体呼吸功能损害，且随着束缚时间增加，以上各项指标改变加剧。结论：束缚应激所致的线粒体膜损伤及其效应是应激性心肌损伤的重要机制。
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| 关 键 词： | 束缚应激 损伤 线粒体膜 心肌 |
| 文章编号： | 1002-0837(2003)01-0032-04 |
| 修稿时间： | 2002年2月10日 |
Study on Mitochondrial Membrane Mechanism of Rat Heart Injury Induced by Constrainting Stress |
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| REN Hui rong,QIAN Ling jia,GONG Jing bo,WANG Xin xing,REN Chong yu.Study on Mitochondrial Membrane Mechanism of Rat Heart Injury Induced by Constrainting Stress[J].Space Medicine & Medical Engineering,2003,16(1):32-35. |
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| Authors: | REN Hui rong QIAN Ling jia GONG Jing bo WANG Xin xing REN Chong yu |
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| Institution: | Institute of Hygiene & Environmental Medicine, Tianjin, China. |
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| Abstract: | Objective To investigate the effect of constrainting stress on biological characters and function of mitochondrial membrane in rat heart and to explore the possible mitochondrial membrane mechanism underlying stress induced heart injury. Method Stress animal model was established.After constrained for different times,all rats were killed and several indexes were examined. Result Constrainting stress can induce mitochondrial permeability transition,decrease of mitochondrial membrane fluidity,increase of the production of membrane lipid peroxidation and injury of mitochondrial respiratory function which is in time dependent manner.Conclusion Mitochondrial membrane impairment and its effects are the important mechanism of stress induced heart injury. |
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| Keywords: | constrainting stress injuries mitochondrial membranes myocardium |
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