Steroidal glycosides from the rhizomes of Dioscorea spongiosa |
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Authors: | Yin Jun Kouda Kyoji Tezuka Yasuhiro Tran Quan Le Miyahara Tatsuro Chen Yingjie Kadota Shigetoshi |
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Affiliation: | Institute of Natural Medicine and Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan. |
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Abstract: | A water extract of the rhizomes of Dioscorea spongiosa, which showed antiosteoporotic activity, was examined, and four new pregnane glycosides, named spongipregnolosides A-D (1-4), and two new cholestane glycosides, named spongiosides A (5) and B (6), were isolated together with 15 known glycosides. Their structures were determined on the basis of spectroscopic analysis and chemical methods. Among the isolated compounds, spongioside A (5), hypoglaucin G (7), methylprotodioscin (8), and (R)-oct-1-en-3-yl O-alpha-l-arabinopyranosyl-(1-->6)-alpha-d-glucopyranoside (9) showed potent inhibition against bone resorption induced by parathyroid hormone in a bone organ culture system. |
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