On the Theory of Ion Transport Across the Nerve Membrane, VII. Cooperativity Between Channels of a Large Square Lattice |
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| Authors: | Yi-Der Chen and Terrell L. Hill |
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| Affiliation: | 1.Laboratory of Molecular Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014 |
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| Abstract: | The exact kinetics of a 10 x 10 Ising system (periodic boundary conditions) with two-state channels arranged in a square lattice was studied by computer simulation. With all three values of the cooperativity parameter used, no induction in the K(+)-current curve was obtained. This confirms one of our previous conclusions concerning K(+) channels in the squid axon membrane: models with interacting channels arranged in a twodimensional lattice (Adam's model) are apparently excluded. Other topics included: equilibrium properties; short-range pair correlation functions; phase transition. |
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