γ δ T cells participate in the immune response against activated, myelin basic protein-specific, human T cells |
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Authors: | James Burns Breck Bartholomew Kim Littlefield |
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Institution: | Veterans Administration Medical Center, Neurovirology Research 151B, Department of Neurology, University of Utah School of Medicine, 500 Foothill Drive, Salt Lake City, UT 84148, USA |
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Abstract: | γδ T cells are over-represented in some multiple sclerosis (MS) parenchymal lesions and in the cerebrospinal fluid (CSF) of individuals with early MS. In this investigation we studied the T cell-T cell interactions between human, myelin basic protein-reactive T cells and peripheral blood mononuclear cells (PBMC) isolated from MS and control subjects. We detected brisk proliferation by PBMC in response to activated, but not resting, MBP-specific T cells. The magnitude of proliferation approached that induced by superantigens and was distinctly greater than the response to standard recall antigens. Examination of the responding T cells revealed predominant expansion of T cells using γδ rather than αβ T cell receptors. This finding suggests that the accumulation of γδ T cells noted in some MS parenchymal lesions may represent recruitment by activation markers expressed by other T cells in these lesions. The response to activated but not resting MBP-specific T cells may parallel observations that protective T cell vaccination in experimental encephalomyelitis is more effective using activated rather than resting, myelin-specific T cells. |
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Keywords: | Multiple sclerosis Gamma delta T cells Anti-ergotypic response Myelin basic protein |
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