妊娠期糖尿病母鼠血清晚期糖基化终产物与子鼠心脏发育异常的关系 |
| |
引用本文: | 柳国胜,吴瑕,刘海英,赵立华,康举龄,李小毛,肖作源.妊娠期糖尿病母鼠血清晚期糖基化终产物与子鼠心脏发育异常的关系[J].中华围产医学杂志,2000,12(1):209-212. |
| |
作者姓名: | 柳国胜 吴瑕 刘海英 赵立华 康举龄 李小毛 肖作源 |
| |
作者单位: | 暨南大学附属第一医院新生儿科,广州,510632;山东省即墨市中医院儿科;暨南大学附属第一医院,病理科,广州,510632;中山大学附属第三医院妇产科;中山大学附属第三医院妇产科,儿科; |
| |
摘 要: | Objective To explore the effect of advanced glycation end product(AGE) in serum of maternal rats with gestational diabetes mellitus (GDM) on the heart development of their offsprings. Methods Fifty-four SD rats were randomly assigned into control group (n= 24) and GDM group (n=30) which were established by administration of streptozotocin intra-abdominally. On the gestational age of 13, 16, 19 days, all rats underwent hysterectomy to obtain the fetal heart tissues. Serum level of AGE and blood glucose level of maternal rats were tested. The expression of receptor AGE (RAGE) in fetal cardiac tissue were detected by immunohistoehemistry. Results The incidence of fetal heart defect in GDM group was significantly higher than the control group at each time point (P<0.01). Rats in GDM group had higher blood glucose level at each time point (P<0.01). The AGE levels of GDM group on gestational age of 13, 16 and 19 day (5.72±0.68) U/mgpr, (7.31±0.29) U/mgpr and (7.77±0.39) U/mgpr] were significantly higher than those of the control group (4.45±0.27) U/mgpr, (4.71±0. 35) U/mgpr and (4. 37±0. 44) U/rngpr] (t=6. 142, 16. 295, 0. 399,P<0. 01). The number of heart malformation in fetal rats (r=0.994,P=0. 000) and blood glucose (r=0. 717,P=0. 000) had the positive relationship with the maternal serum AGE level. The expression of RAGE in fetal heart was positively related with the number of fetal heart malformation (r= 0. 638,P= 0. 004). Conclusions The increased maternal serum AGE level in GDM rats may be an important factor in fetal heart dysplasia.
|
关 键 词: | 糖尿病 妊娠 糖基化终产物 高级 受体 免疫 糖尿病 实验性 心脏缺损 先天性 |
Relationship between the advanced glycation end products in gestational diabetes mellitus rats and its newborns heart development |
| |
Abstract: | |
| |
Keywords: | Diabetes gestationalGlyeosylation end products advancedReceptor S immunologicDiabetes mellitus experimentalHeart defects congenital |
|
|