syndecan-1在结直肠癌中的表达及意义

目的研究syndecan-1在结直肠癌中的表达，探讨它与肿瘤生长和预后的关系。方法采用免疫组织化学染色技术，检测syndecan-1在结直肠癌及其周围正常组织中的表达，初步分析它与结直肠癌临床病理特征和临床预后的关系。结果3l例肿瘤组织切片中，syndecan-1表达阳性者仅1例（3．2％），正常组织中syndecan-1表达阳性者29例（93．5％），syndecan-1表达阳性率在两组间的差异有统计学意义（P〈0．01）。syndecan-1主要表达在正常肠黏膜上皮，肿瘤间质中的表达呈弱阳性。结论syndecan-1主要表达在正常结直肠黏膜上皮，肿瘤细胞中极少表达。

Syndecan-1 Protein Expression in Colorectal Cancer

Objective Heparan sulfate proteoglycans (HSPGs) is an important component of the extracellular matrix. syndecan-1, a member of syndecan family, belongs to HSPGs and plays an important role in cell morphology and intracellular arrangement. The present study was designed to investigate the expression of syndecan-1 in patients with colorectal cancer, to analyse its relationship to cancer progression and clinical prognosis. Methods Paraffin-embeded specimens were collected from 31 patients with colorectal cancers from 2003 to 2004 in Peking Union Medical College Hospital. Syndecan-1 protein expression was measured by immunohistochemistry. Its expression was evaluated with relationship to clinicopathological factors, including tumor infiltration, tumor differentiation, lymph node metastasis, accompanying with colorectal adenoma and 2-year survivals. Results Immunohistochemistry in 31 specimens showed syndecan-1 were detected positive in 1 colorectal cancer tissue (3.2%), while positive in 29 normal tissues (93.5%), with significant difference (P<0.01). No prognostic differences could be found in the clinic outcome because of the high expression rate of syndecan-1 in normal tissues and low expression rate in cancer tissues. Conclusion Syncecan-1 is expressed in normal colorectal tissues and rarely expressed in cancer tissues.