Preparation and antibacterial activity of 3-methyl-1-p-substituted phenylpyrazole-5-thiol |
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| Authors: | Tagawa Yoshinobu Minami Shin'ichi Yoshida Toshio Tanaka Keitaro Sato Shuji Goto Yoshinobu Yamagata Kenji |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. tagawa@fukuoka-u.ac.jp |
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| Abstract: | 3-Methyl-1-phenylpyrazole-5-thiol (3a) and its p-nitro- (5) and p-fluorophenyl (8) derivatives were prepared as potential antimicrobial agents in relatively good yields. Compounds 3a and 8 showed good antibacterial activities against MRSA, S. aureus, S. epidermidis, E. faecalis, E. faecium, and S. pyogenes. Moreover, compound 3a also showed a synergistic effect with some aminoglycosides. |
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