| 避蚊胺-海藻酸钙微球的制备及其体外透皮吸收研究 |
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| 引用本文： | 胡晏, 王苏莉, 余伟民, 崔景斌. 避蚊胺-海藻酸钙微球的制备及其体外透皮吸收研究[J]. 中国现代应用药学, 2008, (2): 120-122. |
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| 作者姓名： | 胡晏 王苏莉 余伟民 崔景斌 |
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| 作者单位： | 华东理工大学药学院,上海,200237 |
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| 摘 要： | 目的 制备海藻酸钙空白微球,减少避蚊胺(DEET)的透皮吸收,延长其作用时间.方法采用溶剂挥发法制备海藻酸钙微球,采用光学显微镜和激光粒度仪考察微球特性;吸附DEET后制成霜荆,通过Franz扩散池,用气相色谱法考察含药微球的透皮吸收.结果所得微球外观圆整,平均粒径42.5μm,吸附量为1.2177 g·g-1.透皮试验结果表明,海藻酸钙空白微球能延长DEET的释放,减少皮肤渗透.结论 海藻酸钙微球具有显著的缓释效果,并减少DEET对人体及皮肤的不良反应.
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| 关 键 词： | 避蚊胺 海藻酸钙微球 吸附 皮肤渗透 |
| 文章编号： | 1007-7693(2008)02-0120-03 |
| 修稿时间： | 2007-06-21 |
Preparation of DEET-calcium Alginate Microspheres and Evaluation of Its Percutaneous Penetration |
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| HU Yan, WANG Su-li, YU Wei-min, CUI Jing-bin. Preparation of DEET-calcium Alginate Microspheres and Evaluation of Its Percutaneous Penetration[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (2): 120-122. |
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| Authors: | HU Yan WANG Su-li YU Wei-min CUI Jing-bin |
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| Abstract: | OBJECTIVE Calcium alginate microsphere was prepared to decrease the percutaneous penetration of DEET for sustained release.METHODS The microsphere was prepared by solvent evaporation method and its property was characterized by the optical microscope and |
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| Keywords: | DEET calcium alginate microsphere adsoption percutaneous penetration |
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