A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. |
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Authors: | P G Coulie F Lehmann B Lethé J Herman C Lurquin M Andrawiss T Boon |
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Affiliation: | Ludwig Institute for Cancer Research, UCL 7459, Brussels, Belgium. |
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Abstract: | We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions. |
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