DNA修复基因XPC单核苷酸多态性与膀胱癌易感性的meta分析

【目的】用Meta分析的方法探讨DNA修复基因XPC单核苷酸多态性与膀胱癌的易感性。【方法】计算机检索Pubmed数据库、Embase数据库、中国生物医学文献数据库（CBM）收集关于DNA修复基因XPCAla499Val及Lys939Gln单核苷酸多态性与膀胱癌易感性的病例对照研究进行Meta分析，以野生基因型为参照，病例组及对照组XPC499Val、939Gln等位基因分布的比值比（OR）为效应指标，应用Meta分析软件Stata9．0对各研究原始数据进行统计处理及异质性检验，计算合并OR值及95％CI。【结果】按照纳入标准，最终进人Meta分析的文献共有7篇。Meta分析结果显示，XPC499Val／Val突变纯合子的个体发生膀胱癌的风险要高于对照组（合并OR=1．31；95％CI：1．06～1．62）。而XPC939Gin／Gin与膀胱癌之间无显著相关性。【结论】XPCAla499Val多态性与膀胱癌易感性之间存在相关，即携带突变型基因纯合子499Val／Val的个体发生膀胱癌的危险性较高。

Meta analysis on DNA repair gene XPC single neucleotide polymorphisms and bladder Cancer

Objective] To investigate the association between DNA repair gene XPC single neucleotide polymorphisms and bladder cancer risk by meta analysis. Methods] Computer retrieval was carried out in Pubmed, Embase and CBMdisc to identify relevant case control studies for meta analysis. The odds ratios （OR） of variant allele of XPC 499Val and 939Gln was calculated as referenced with the wildtype. The meta analysis was performed by Stata 9.0 software package for heterogeneity test and the OR poohing analysis. Results] 7 ease control studies were identified for meta analysis. The XPC Ala/Ala499Val/Val variant homologous genotype （Val/Val） was associated with increased bladder cancer risk and the pooled OR was 1.31 （95% CI： 1.06-1.62） while variations in XPC Lys/Lys939Gln/Gha was not associated with altered bladder cancer risk. Condusions] The XPC 499Val/Val genotype may contribute to the risk of bladder cancer.