| 白塞病与HLA的相关性 |
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| 引用本文： | 黄正吉,俞碧娥,唐观甜,黄志基.白塞病与HLA的相关性[J].现代免疫学,1987(4). |
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| 作者姓名： | 黄正吉 俞碧娥 唐观甜 黄志基 |
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| 作者单位： | 上海医科大学华山医院皮肤科
(黄正吉，俞碧娥)，上海医科大学华山医院免疫室
(唐观甜)，上海医科大学华山医院免疫室(黄志基) |
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| 摘 要： | 本文以 NIH标准微量淋巴细胞细胞毒试验对上海地区所见41例白塞(Behcet)病进行了HLA-A·B位点检测。211例正常人作为对照。41例中B_5 抗原频率为48.1％,约为对照16.1％的 3倍。RR=490,x~2=19.8611,p<0.00001,有极显著意义。在我国各民族中是最高的,与国外报告资料相一致。皮肤针刺反应与B_5 抗原一致阳性为41.4％,这对诊断本病有帮助。
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THE ASSOCIATION BETWEEN BEHCET'S DISEASE AND HLA |
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| Abstract: | HLA-A and B locus were determined by NIH standard microlymphocytotoxicity test on serum from 41 patients with Behcet's disease and 211 normals as a control. In 41 cases, the B5 frequency was almost 3 times higher than the controls (48.7% V. S 16.1%). RR = 4.90, X2= 19.8611, P<0.00001. The results showed that the distribution of B6 antigen between the patients and controls was statistically significant. This frequency was the highest among various nationlities of our country .however it was in accordance with the reports from Japan, Turkey, etc. The positivity to the needle prickle reaction and B5 antigen were 41.4% respectively, it suggested that positive results for both may be helpful to the diagnosis. |
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