Identification of testosterone-dependent volatile compounds and proteins in the preputial gland of rat Rattus norvegicus |
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Authors: | Ponnirul Ponmanickam Shanmugam Govindaraj Yoshiaki Habara |
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Affiliation: | a Center for Pheromone Technology, Department of Animal Science, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India b Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India c Laboratory of Physiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan |
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Abstract: | Preputial gland is one of the best known and most odour-producing organs in many non-primate mammals. It is generally believed that the development of this gland and functions are regulated by testosterone. To substantiate this point, the present study was aimed to evaluate the testosterone-dependent volatile compounds and proteins in the preputial gland of rat adopting castration and testosterone supplementation. The results revealed that four compounds, geranyl linalool isomer, oxirane, farnesol and lanosterol, are testosterone-dependent. Similarly, a low molecular mass protein with molecular weight 18 kDa, supposed to be a pheromone carrier, also is shown to be testosterone-dependent. This study leads to the conclusion that testosterone-dependent compounds and sex-associated protein are present in the preputial gland of rat which may act as a sex pheromone and pheromone carrier, respectively. |
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Keywords: | Castration Testosterone Preputial gland Volatile compounds Sex-associated proteins Rat |
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