癌症恶病质与肿瘤坏死因子关系的临床研究

 目的　初步探讨肿瘤坏死因子(TNF -α)含量与癌症恶病质的关系。方法　用苯丙酸诺龙及营养支持疗法对19 例恶病质患者治疗三周，观察治疗前后患者血清中TNF-α，体重、右上臂中部周径、三头 肌 皮摺厚度，KPS评分、总蛋白、白蛋白的变化，并与17例健康对照组进行比较。结果 　疾病组治疗前TNF-α值明显高于对照组(P＜0.01)，治疗后TNF-α值较治 疗前明显下降(P＜0.01)，并接近对照组，治疗后其余各项指标较治疗前均增加，病 情好转时TNF-α值是下降的。结论　TNF-α可能是参与恶病质过程的重要 细胞因子之一，其水平高低与病情轻重相关联。

A Clinical Study of Cachexia and its Relationship to Tumo r Necrosis Factor

Objective To explore the association between tumor necros is factor and cachexia.Methods 19 cancer patients with cachexia and 17 healthy individuals were treated with durobolin.Comparisons were made in the b lood TNF-α,TP,Alb,body weight and KPS,before and after treatment,between the t wo groups.Results The level of serum TNF-α in cancer group was sig ni ficantly higher than that of control group before treatment (P＜0.01).Afte r treatment the level of serum TNF-α was decreased as compare to the level bef ore treatment(P＜0.01).Conclusion The results suggested that the mechanism of cachexia may be related to TNF-α.