| COX-2与P73在胃癌中的表达及相关性探讨 |
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| 引用本文： | 陈旭权. COX-2与P73在胃癌中的表达及相关性探讨[J]. 放射免疫学杂志, 2009, 22(2): 150-152 |
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| 作者姓名： | 陈旭权 |
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| 作者单位： | 浙江省乐清市第二人民医院普外科,325608 |
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| 摘 要： | 目的：探讨COX-2和P73在胃癌组织中的表达及临床意义。方法：应用免疫组化Envision法检测COX-2和P73在62例胃癌组织中的表达情况。结果：全组COX-2阳性率为64.5%（40/62），P73阳性率为69.4%（43/62）。COX-2的表达与组织分化程度、浸润深度、淋巴结转移和临床TNM分期相关（P〈0.05）；P73的表达与浸润深度、淋巴结转移和临床TNM分期相关（P〈0.05）。COX-2和P73同时表达、单独表达及不表达时，胃癌的组织分化程度、病变浸润深度（T分期）、淋巴结转移（N分期）和临床分期组间差异有统计学意义（P〈0.05）。COX-2和P73在胃癌组织中的表达具有相关性（r=0.384，P〈0.05）。结论：胃癌组织中存在COX-2和P73基因的过度表达，COX-2和P73基因的过度表达与胃癌发生发展有关。
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| 关 键 词： | 胃癌 环氧化酶-2 P73 |
Clinical Significance of Expression of COX-2 and P73 in Gastric Carcinoma Tissue |
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| Chen Xuquan. Clinical Significance of Expression of COX-2 and P73 in Gastric Carcinoma Tissue[J]. Journal of Radioimmanology, 2009, 22(2): 150-152 |
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| Authors: | Chen Xuquan |
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| Affiliation: | Chen Xuquan Department of Surgery,Leqing Municiple Second People's Hospital,Leqing,Zhejiang (325608) |
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| Abstract: | Objective To investigate COX-2 and P73 expression in gastric carcinoma tissue. Methods The expression of COX-2 and P73 in gastric carcinoma tissue were detected with immuno-histochemistry (Envision method) in 62 resected gastric speciments. Results The positive rate of COX-2 and P73 was 64.5%(40/62) and 69.4%(43/62)respectively. Significant correlations were observed between the expression of COX-2 and the clinical factors including degree of differentiation,depth of invasion(r=0.384,P<0.05),lymphaticmetast... |
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| Keywords: | P73 |
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