Cyclin D1和Cyclin B1在鼻咽癌中表达的免疫组织化学研究

目的为探讨Cyclin D1和CyclinB1在鼻咽癌中的表达、相关性及临床意义.方法用免疫组化SP法分别检测Cyclin D1和Cyclin B1在58例鼻咽癌组织标本中的表达.结果Cyclin D1和Cyclin B1在鼻咽癌组织中的阳性表达率分别为58.6%(34/58)和60.3%(35/58);Cyclin D1和Cyclin B1 阳性和阴性病例的平均生存期、五年生存率和中位生存期存在显著性差异(P＜0.05);鼻咽癌组织中Cyclin D1和Cyclin B1的表达一致率为60.3%(35/58),无显著相关.结论Cyclin D1和Cyclin B1表达均可以反映鼻咽癌的生存情况,在鼻咽癌预后预测中有重要意义.

Immunohistochemical study on expression of Cyclin D1 and Cyclin B1 in nasopharyngeal carcinoma

Objective:To investigate Cyclin D1and Cyclin B1expression in nasopharyngeal carcinoma(NPC)and clinical significance,and analyze their relations.Methods:Cyclin D1and Cyclin B1expressions were assayed respectively in58nasopharyngeal carcinoma tissues by immunohistochemical method.Results:The positive expression rates of Cyclin D1and Cyclin B1in NPC were58.6%(34/58)and60.3%(35/58),respectively;The mean survival period,the five-year-survival rate and median survival period in Cyclin D1and Cyclin B1positive expression group were shorter than those in Cyclin D1and Cyclin B1negative ex-pression group(P<0.05);The coincidence expression rate of Cyclin D1and Cyclin B1was60.3%(35/58)and no significant correlation existed between their expressions.Conclusions:Cyclin D1and Cyclin B1expressions may act as important predictors for NPC prognosis.