甲型肝炎病毒在冠心病发病中的意义及致病机制研究

目的 探讨人类甲型肝炎病毒(HAV)感染在冠心病发病中的意义及可能的致病机制。方法 采用中和抑制法对107例冠心病患者血清HAV-IgG抗体进行了检测，同时运用液相免疫沉淀散射比浊法测定了C反应蛋白水平，并与59例非CAD的心血管病人进行了对比观测。结果 CAD患者甲肝lgG抗体阳性为75．7％，明显高于59例非CAD的心血管病人(37.3％)和正常对照组(51．O％)。而CAD组CRP水平与非CAD组没明显差异，但明显高于对照组，CAD组CPP阳性率(55．1％)明显高于非CAD组(30．5％)和正常对照组(15．0％)。结论 HAV的感染可能在CAD疾病的发生及发展过程中起一定的作用。

Detection and it''''s clinical significance of anti-HAVIgG antibodies of 107 patients undergoing coronary artery disease

Objective: To study the possible association between hepatitis A virus (HAV) infection and coronary artery disease (CAD) and the possible mechanism of inflammation in CAD. Methods: Anti-HAV IgG antibody and C-reactive protein were detected from 107 patients undergoing coronary artery disease. Results: HAV-seropositive rate was 75.7% in CAD patients, and it was significantly higher than non-CAD patients(37.3%) and the normal control group (51.0%), and CRP levels were significantly higher in CAD patients than the control group, and it was not significantly changed in CAD patients and non-CAD patients, CRP levels postive rate in CAD patients (55.1%) were significantly higher than the control group (15.0%) and non-CAD patients (30.5 %). Conclusions: HAV infection may associated with CAD, and HAV may play a causal role in atherogenesis.