The role of gamma interferon in infection of susceptible mice with murine coronavirus,MHV-JHM |
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| Authors: | Abigail L Smith S W Barthold M S de Souza Kim Bottomly |
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| Institution: | (1) Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A.;(2) Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, U.S.A.;(3) Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, U.S.A. |
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| Abstract: | Summary Infection of BALB/c mice with mouse hepatitis virus, strain JHM (MHV-JHM), at any of several intervals relative to ovalbumin (OVA) administration resulted in elevated OVA-specific IgG 2 a titers. Since gamma interferon (IFN) has been implicated as an up-regulator of IgG 2 a production, attempts were made to determine whether levels of this cytokine were modified in sera of infected mice. Serum IFN- was not detected, but treatment of MHV-JHM-infected mice with monoclonal anti-IFN- antibody resulted in high mortality with decreased survival times, enhanced virus titers in liver and spleen, and more severe virus-associated pathology, compared to mock-treated, infected mice. Immunotherapy with recombinant IFN- ameliorated disease as reflected by mortality rates and virus titers in target organs. |
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