合肥市健康人群A、C、Y、W135群流行性脑脊髓膜炎抗体浓度水平研究

目的 掌握合肥市健康人群A、C、Y、W135群流行性脑脊髓膜炎(流脑)抗体浓度水平,监测免疫状况和流行趋势,探讨定量监测标准。 方法 应用分层随机抽样方法,以合肥市辖区县划分为7个研究地区,调查流脑流行季节流行前期健康人群945例。应用酶联免疫吸附试验,分析血清样本A、C、Y、W135群流脑抗体浓度水平。 结果 945例健康人群中,A、C、Y、W135群流脑抗体浓度中位数分别是12.06、4.08、2.36、1.25 μg/ml,几何平均浓度(GMC)分别是11.75、4.57、2.32、1.35 μg/ml;Y、W135群流脑抗体浓度单侧百分位数P95分别是8.74 μg/ml和5.60 μg/ml。A、C、Y、W135群流脑抗体浓度不同年龄组之间差异有统计学意义,A群和C群≤1岁最高,21~30岁最低; Y群和W135群21~30岁最高。 结论 合肥市健康人群流脑抗体浓度水平,A群较高,C群偏低,Y、W135群最低。需要规范监测方法,明确定量监测标准,以利于全国不同区域之间资料分析。

Antibody levels to Neisseria meningitidis serogroup A,C,Y and W135 in healthy population in Heifei

Objective To understand the antibody levels to Neisseria meningitidis(Nm)serogroup A,C,Y and W135 in the healthy population in Hefei,monitor the immunization status and incidence trend of the disease as well as discuss the standard of quantitative surveillance.Methods A total of 945 healthy people were selected by stratified random sampling in 7 areas in Hefei and a survey was conducted among them before meningococcal disease season by detecting serogroup A,C,Y and W135 antibodies levels in their serum samples with ELISA.Results In the 945 healthy people,the medians of the antibody concentrations to Nm serogroup A,C,Y and W135 were 12.06,4.08,2.36 and 1.25 μg/ml respectively,the geometric mean concentrations(GMC)were 11.75,4.57,2.32 and 1.35 μg/ml respectively;the percentile P95 of the antibody concentrations to Nm serogroup Y and W135 were 8.74 and 5.60 μg/ml respectively.The differences on antibody levels in different age groups were significant,The antibody levels to serogroup A and C were highest in age group ≤1 year and lowest in age group 21-30 years;and the antibody levels to serogroup Y and W135 were highest in age group 21-30 years.Conclusion Among the healthy population in Hefei,the antibody level to Nm serogroup A was high,but the antibody levels to Nm serogroup C,Y and W135 were low.It is necessary to standardize the surveillance and specify the quantitative standard of the surveillance to facilitate the nationwide data analysis and comparison.