2008-2011年辽宁省锦州市手足口病病原监测结果分析

目的 了解辽宁省锦州地区手足口病的病原学特征及变化趋势,为手足口病防治工作提供参考依据。 方法 日常监测工作中收集2008-2011年锦州地区294例手足口病临床确诊患儿的330份样本检测结果,其中咽拭子274份,粪便标本56份,进行病原学检测。 结果 294例被检测患儿中246例为肠道病毒阳性,阳性率为83.67％,其中肠道病毒71型(EV71)阳性率30.61%,柯萨奇A组16型(Cox A16)阳性率32.31%,EV71、Cox A16混合感染阳性率0.34%,其他肠道病毒阳性率20.41%。330份标本中咽拭子阳性率82.12％(225／274),粪便阳性率71.43%(40/56)。2008-2011年病例的咽拭及粪便标本采用不同检测方法、不同试剂的阳性检出率差异无统计学意义(P﹥0.05)。 结论 锦州市儿童手足口病病原体以EV71和Cox A16为主,每年略有不同,近年其他肠道病毒感染率逐年增高。手足口病患者的咽拭和粪便标本的阳性检出率无差异。

Etiological surveillance of hand foot and mouth disease in Jinzhou city in Liaoning province,2008-2011

Objective To learn about the etiological characteristics of hand foot and mouth disease(HFMD)in Jinzhou and provide evidence for the prevention and control of the disease.Methods The etiological detection was conducted by using 330 samples,including 274 throat swabs and 56 stool samples,collected from 294 clinical confirmed HFMD cases in Jinzhou from 2008 to 2011.Results Among the 294 HFMD cases,the overall detection rate of enteriovirus was 83.67%.The detection rate of EV71 was 30.61%,the detection rate of Cox A16 was 32.31%,the co-infection rate of EV71 and Cox A16 was 0.34% and the detection rate of other enterovirus was 20.41%.Among the 330 samples,the defection rate in throat swabs was 82.12%(225/274),the detection rate in stool samples was 71.43%(40/56).No difference was found on the detection rate between throat swabs and stool samples which was tested by different methods and different reagents(P>0.05).Conclusion EV71 and Cox A16 were the major pathogens to cause hand foot and mouth disease in children in Jinzhou,although the predominance was slightly different in each year.The infection rate of other enterovirus was in increasing year by year.There was no significant difference on the detection rate between throat swabs and stool samples collected from HFMD patients.