山东省淄博市病毒性脑炎病例实验室检测及流行病学分析

目的 掌握山东省淄博市病毒性脑炎的发病率及流行特征。 方法 采集2010年7-10月山东省淄博市报告的病毒性脑炎病例血清和脑脊液标本。对报告的病毒性脑炎病例标本进行5种病毒 的血清学检测,检测相关病毒IgM抗体,同时将部分标本(68份血清和6份脑脊液)进行5种病毒核酸检测。 结果 共报告304例病毒性脑炎病例,病毒抗体和/或病毒核酸阳性的病例112例,其中埃可和柯萨奇病毒阳性病例最多,共59例(19.4%),依次为乙脑病毒阳性病例30例(9.9%)、腮腺炎病毒15例(4.9%)和单纯疱疹病毒8例(2.6%)。82.5%的病毒性脑炎病例为40岁年龄组共25例,占总乙脑病例的83.3%。报告的乙脑病例主要集中在9月和10月,共23例,占总乙脑病例的70.0%。 结论 山东省淄博市病毒性脑炎发病率为7.7/10万,乙脑发病率为0.8/10万,呈现典型的成年人乙脑流行特征。

Epidemiological characteristics of viral encephalitis cases detected in Zibo,Shandong province

Objective To understand the epidemiological characteristics of viral encephalitis(VE) in Zibo,Shandong province.Methods The serum and cerebrospinal fluid(CSF) samples from reported VE cases were collected in Zibo from July to October,2010.The laboratory confirmation of these cases was conducted through serological detections of IgM of Japanese encephalitis virus(JEV),echovirus,coxsackie virus(CoxV),herpes simplex virus(HSV) and mumps virus(MV),and the viral nucleic acid detections of the 5 viruses were conducted for partial samples(68 serum samples,6 CSF samples).Results A total of 304 clinical VE cases were reported,in which,112 were IgM antibody or RT-PCR positive(36.8%).The most common pathogens were echovirus and CoxV(totally 59 cases,19.4%),followed by JEV(30 cases,9.9%),MV(15 cases,4.9%) and HSV(8 cases,2.6%).Up to 82.5% of the VE cases were children under the age of 15 years.Twenty five Japanese encephalitis cases(83.3%) occurred in age group ≥40 years.The reported Japanese encephalitis(JE) cases mainly occurred in September and October(23 cases,70.7%).Conclusion The overall incidence of VE was 7.7/lakh in Zibo,and the incidence of JE was 0.8/lakh,the disease mainly occurred in adults.