| 刺山柑果实醇提物及不同萃取部位的抗炎与镇痛活性研究 |
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| 引用本文： | 杨涛,于富生,王长虹,王峥涛.刺山柑果实醇提物及不同萃取部位的抗炎与镇痛活性研究[J].上海中医药大学学报,2009(1):38-41. |
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| 作者姓名： | 杨涛 于富生 王长虹 王峥涛 |
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| 作者单位： | 上海中医药大学中药研究所中药标准化教育部重点实验室;上海中药标准化研究中心;新疆华世丹药物研究有限公司; |
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| 基金项目： | 上海市教委科研基金资助项目(05CZ31);;上海市重点学科建设资助项目(Y0301) |
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| 摘 要： | 目的：对刺山柑果实乙醇提取物及不同萃取部位的抗炎与镇痛活性部位进行筛选。方法：采用乙醇对刺山柑进行提取制备总提取物，用水溶解后分别用石油醚、乙酸乙酯进行萃取得到石油醚部位、乙酸乙酯部位和水溶性部位。以阿斯匹林为阳性对照药，分别采用二甲苯致小鼠耳廓肿胀实验、小鼠腹腔毛细血管通透性实验、热板法镇痛实验和醋酸扭体镇痛实验进行抗炎镇痛活性部位进行筛选。结果：结果显示乙酸乙酯部位和水溶性部位对二甲苯致小鼠耳肿胀有明显抑制作用；乙酸乙酯部位对小鼠毛细血管通透性有明显抑制作用；乙酸乙酯部位和石油醚部位可显著提高小鼠热板痛阈值，而乙酸乙酯部位和水溶性部位则能明显减少醋酸所致小鼠扭体次数。结论：刺山柑果实具有潜在的抗炎和镇痛作用。
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| 关 键 词： | 刺山柑 抗炎 镇痛 |
Anti-inflammatory and Analgesic Effects of Ethanol Extract and Isolated Fraction from Fruits of Capparis spinosa |
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| YANG Tao YU Fu-sheng WANG Chang-hong WANG Zheng-tao .Key Laboratory of St,ardization of Chinese Medicines of Ministry of Education,The Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine .R&D Centre for St,ardization of Chinese Medicines, Guoshoujing Road .Xinjiang Huashidan Pharmaceutical Research Co.Ltd..Anti-inflammatory and Analgesic Effects of Ethanol Extract and Isolated Fraction from Fruits of Capparis spinosa[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2009(1):38-41. |
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| Authors: | YANG Tao YU Fu-sheng WANG Chang-hong WANG Zheng-tao Key Laboratory of St ardization of Chinese Medicines of Ministry of Education The Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine R&D Centre for St ardization of Chinese Medicines Guoshoujing Road Xinjiang Huashidan Pharmaceutical Research CoLtd |
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| Institution: | 1;2;1;2;1;2 |
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| Abstract: | Objective:To screen the anti-inflammatory and analgesic effects of ethanol extract and isolated fraction from Capparis spinosa.Methods:The different fractions of petroleum ether,acetic ether,water solubility,and total ethanol extracts of Capparis spinosa L fruits were prepared with extraction,respectively.The swelling of auricle test induced with dimethyl benzene,abdominal capillary permeability test,writhing test induced with ethanoic acid,and thermal plate test were employed to screen the active fractions... |
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| Keywords: | Capparis spinosa anti-inflammation analgesic |
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