腺苷蛋氨酸对慢性乙型重型肝炎患者抑郁情绪干预治疗的疗效观察

目的探讨腺苷蛋氨酸（思美泰）对慢性乙型重型肝炎抑郁情绪干预治疗的疗效。方法将49例慢性乙型重型肝炎患者随机分为：观察组（32例），即在常规内科综合治疗基础上加用思美泰治疗；对照组（17例），即常规内科综合治疗。两组分别在治疗前、治疗2周和治疗4周时，采用汉密尔顿抑郁量表（HAMD 17）评定抑郁情绪分值。结果观察组HAMD评分从治疗2周起开始下降，但在2周时两组间比较差异无统计学意义，而至第4周末观察组HAMD评分显著下降，两组间差异有统计学意义（P〈0.05）。结论腺苷蛋氨酸在治疗重型肝炎的同时，对慢性乙型重型肝炎患者抑郁情绪也有一定干预治疗作用。

Effect of ademetionine on patients with depressed emotion and chronic severe hepatitis B: an initial study

Objective To explore the curative effect of ademetionine in treatment of patients with depressed emotion and chronic severe hepatitis B.Methods All of 49 patients with chronic severe hepatitis B were randomly divided into experiment group（basic medical treatment combined with ademetionine,n=32） and control group（only basic medical treatments,n= 17）.Clinical effect were assessed with Hamilton Anxiety Scale（HAMA 17） before and after 2 weeks,4 weeks treatment.Results After 2 weeks＇ treatment,the score of the HAMA decreased gradually in the experiment group,which was not significantly different compared with control group and decreased more significantly in the experiment group after 4 weeks＇ treatment,with lower score than that in control group（P 0.05）.Conclusions Ademetionine has significant effect on treatment of patients with depressed emotion and chronic severe hepatitis B.