饮食疗法对多囊卵巢综合征患者人体测量学和胰岛素敏感性的影响

目的 探讨饮食干预对多囊卵巢综合征患者体质量及胰岛素敏感性的影响.方法 2009年6月至2010年2月在复旦大学附属妇产科医院内分泌专科门诊入选31例多囊卵巢综合征患者(年龄19 ～30岁),根据体质指数将其分至肥胖多囊卵巢综合征组(n=17,体质指数≥25 kg/m2)和非肥胖多囊卵巢综合征组(n=14,体质指数＜2...

Effects of dietary intervention on body weight and insulin sensitivity of patients with polycystic ovary syndrome

Objective To investigate the effects of dietary intervention on body weight and metabolic profiles in patients with polycystic ovary syndrome ( PCOS).Methods A total of 31 PCOS patients aged 19 to30 years were assigned to group A (n =17,body mass index (BMI)≥25 kg/m2) or group B ( n =14,BMI ＜ 25 kg/m2 ).Anthropometric measurements and hormonal and metabolic profiles were compared in each group before and after the intervention.Results Body weight,BMI and waist circumference of group A were significantly decreased at 1 month ( t values were 4.82,4.79 and 3.32,respectively; all P＜0.05),and fasting plasma insulin ( ( 13 ±6) mU/L vs (21 ±7) mU/L) and HOMAIR (0.9 ± 0.5 vs 1.5 ± 0.5 ) were largely improved (t values were 4.75 and 5.92,respectively; both P ＜0.01 ).At 3 months,body weight,BMI and fasting plasma insulin were still decreased (t values were 4.41,4.28 and 5.92,respectively; all P ＜ 0.05 ).Body weight,BMI and waist circumference of group B were significantly decreased at I month ( t values were 4.41,4.28 and 5.14,respectively; all P ＜ 0.01 ),and fasting plasma insulin ( (7.1 ± 2.5) mU/L vs ( 15.2 ± 1.5 ) mU/L) and HOMA-IR (0.42 ± 0.38 vs 1.16 ±0.09) were improved (t values were 4.44 and 3.27,respectively; both P ＜0.05) at 3 months.Conclusion Dietary intervention could improve anthropometric measurements and metabolic profiles in nonobese or obese women with PCOS.