血清高敏C反应蛋白与妊娠糖尿病的相关性研究

目的探讨血清高敏C反应蛋白（hsC-RP）水平与妊娠糖尿病（GDM）的相关性。方法在妊娠中晚期检测孕妇的血清hsC-RP水平。将患GDM的306例孕妇作为病例组（GDM组），糖耐量正常的347名孕妇作为对照组（Con组），比较两组的血清hsC-RP水平，再按hsC-RP水平四分位，将研究对象分为4组，进行Logistic回归分析。结果GDM组的血清hsC-I中位数水平明显高于Con组（3．01m4g／LVS2．15mg／L，P〈0．01）。根据hsC-RP水平四分位的结果，将研究对象分为4组，第1组hsC-RP〈1．41mg／L，第2组hsC-RP1．41～2．41mg／L，第3组hsC-RP2．42～4．60mg／L，第4组hsC-RP≥4．61mg／L，相应的GDM的检出率分别为36．81％、42．68％、48．47％、59．51％。调整年龄、孕次、孕前BMI、SBP、DBP及糖尿病家族史等因素，行Logistic回归分析发现，hsC-RP是GDM的独立危险因素（OR值为1．27，95％CI为1．08～1．49，P％0．01）。结论GDM患者妊娠中晚期hsC-RP水平明显升高，慢性炎症可能参与了GDM的发生。

Association of highsensitive C-reactive protein with gestational diabetes mellitns

Objective To investigate the relevance between high sensitive C-reactive protein（hsC- RP） and gestational diabetes mellitus （GDM）. Methods In the late second or early third trimester, serum levels of hsC-RP were measured. This study included randomly the 306 women who developed GDM and 347 women who remained euglycemic throughout pregnancy. Median hsC-RP levels were compared using Wileoxon＇ s rank-sum test. Logistic regression was used to compute unadjusted and multivariable-adjusted odds ratios for developing GDM among hsC-RP quartiles. Results Median hsC- RP levels were significantly increased in GDM subjects as compared with control pregnant women （3.01 mg/L vs 2.15 mg/L,P〈0. 01）. The serum hsC-RP values for the first to the fourth quartile were 0.15~ 1.40 mg/L, 1.41 ~ 2.41 mg/L, 2.42 ~ 4.60 mg/L, 4.61 ~ 10.00 mg/L, respectively. Detection rate of GDM for the respective quartiles were 36.81%, 42.68%, 48.47%, 59.51%o After adjusting for age, parity, and family history of diabetes, an independent contribution of hsC-RP to risk of GDM could be confirmed（odds ratio=1. 27,95% confidence interval：1. 08~1.49,P〈0.01）. Conclusions In GDM women, there is evidence of increased serum levels of hsC-RP in the late second or early third trimester. Systemic inflammation may be associated with the development of GDM.