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| 磁性聚乳酸-羟基乙酸氧化苦参碱纳米粒的制备及其特性 | |
| 引用本文： | 郑智武,陈岳祥,陈伟忠,宋春燕,钱慧,高静.磁性聚乳酸-羟基乙酸氧化苦参碱纳米粒的制备及其特性[J].生物医学工程与临床,2012,16(3):213-217. |
| 作者姓名： | 郑智武 陈岳祥 陈伟忠 宋春燕 钱慧 高静 |
| 作者单位： | 1. 解放军第411医院消化内科,上海,200081 2. 第二军医大学长征医院消化内科,上海,200003 3. 第二军医大学药学院药剂学教研室,上海,200433 |
| 基金项目： | 2005年上海市卫生局科技发展基金(054123) |
| 摘 要： | 目的研究磁性聚乳酸-羟基乙酸氧化苦参碱纳米粒(M-PLGA-OM-NP)的制备工艺,并对纳米粒子进行评价。方法运用复乳法制备M-PLGA-OM-NP,通过透射电子显微镜观察纳米粒形态,并对纳米粒的平均粒径、载药量、包封率、体外释药情况等进行评价。结果纳米粒外观呈规则球形,其平均粒径为146.5 nm,载药量为7.61%,包封率为44.8%。突释后至第72小时,纳米粒维持较稳定的释药速度,累积释放达52.9%。72～240 h,药物释放缓慢,累计释放约为16.6%,体外释放符合Ritger peppas方程lny=1.280 6+lnt。氧化苦参碱药性不受温度影响。结论获得了较满意的M-PLGA-OM-NP制备工艺,其过程简单,粒子性状符合要求。 |
| 关 键 词： | 氧化苦参碱 聚乳酸-羟基乙酸 磁性纳米粒 |
Preparation and characterization of magnetic poly D,L-lactide-co-glycolide oxymatrine nanoparticles |
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| ZHENG Zhi-wu , CHEN Yue-xiang , CHEN Wei-zhong , SONG Chun-yan , QIAN Hui , GAO Jing.Preparation and characterization of magnetic poly D,L-lactide-co-glycolide oxymatrine nanoparticles[J].Biomedical Engineering and Clinical Medicine,2012,16(3):213-217. | |
| Authors: | ZHENG Zhi-wu CHEN Yue-xiang CHEN Wei-zhong SONG Chun-yan QIAN Hui GAO Jing |
| Institution: | 1.Department of Gastroenterology,PLA No.411 Hospital,Shanghai 200081,China;2.Department of Gastroenterology,Shanghai Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;3.Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
| Abstract: | Objective To study the preparation technique for magnetic poly D,L-lactide-co-glycolide oxymatrine nanoparticles(M-PLGA-OM-NP) and to characterize the resultant product.Methods M-PLGA-OM-NP were prepared by using multiple emulsion process.The morphology of the prepared nanoparticles was observed by transmission electron microscope.The mean diameter,encapsulation ratio,and drug loading rate of the particles were also evaluated.Results The nanoparticles had a regular spherical surface.The mean diameter of the nanoparticles was 146.5 nm.The mean drug loading and entrapment efficiency were 7.61 % and 44.8 % respectively.Among burst release and 72 hours,nanoparticles maintained a stable release rate,cumulative release amount to 52.9 %.It maintained slow drug release at 72-240 hours,cumulative release about 16.6 %.In vitro release conformed to Ritger peppas equation,lny = 1.280 6 + lnt.Conclusion It is demonstrated that M-PLGA-OM-NP with satisfactory quality could be obtained using this method,which can meet the requirement of pharmaceutics. |
| Keywords: | oxymatrine poly D L-lactic-co-glycolic acid magnetic nanoparticles |
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