肾气丸对2型糖尿病胰岛素抵抗模型大鼠血清瘦素的影响

目的:探讨金匮肾气丸对2型糖尿病胰岛素抵抗大鼠血清瘦素的影响。方法:40只SD大鼠采用高脂高糖饲料喂养3周,小剂量链脲佐菌素(STZ)腹腔注射诱导2型糖尿病胰岛素抵抗大鼠,随机分为模型组、二甲双胍组、肾气丸高剂量组、肾气丸低剂量组4组,每组10只。另设正常组10只,饲以普通饲料。给药6 w后处死大鼠,末次给药后禁食12 h,检测空腹血糖(FBG)、血清胰岛素(FINS)、血清瘦素(LEP),计算胰岛素抵抗指数(HOMA-IR)。结果:与正常组比较,模型组空腹血糖、血清胰岛素水平、HOMA-IR、血清瘦素水平均明显增高(P<0.01);与模型组比较,二甲双胍组、肾气丸高、低剂量组空腹血糖、血清胰岛素水平、HOMA-IR、血清瘦素水平均明显降低(P<0.05,P<0.01)。结论:金匮肾气丸可降低LEP、HOMA-IR,增强胰岛素的敏感性。

The Effects of Jingui Shenqi Pill on Leptin in Rats with Type 2 Diabetes

Objective:To study the effects of Jingui Shenqi pill on Leptin in rats with type 2 diabetes.Methods:40 SD rats were fed with high fat and sugar for 3 weeks,type 2 diabetes model rats of insulin resistant induced by intraperitoneal injection of Streptozotocin(STZ)were randomly divided into model group,metformin group,Shenqi pill high dose group,Shenqi pill low dose group(n=10).10 rats were selected as normal group.The rats were itragastrically administrated for 6 w,then rats were sacrificed.Fasting blood-glucose(FBG),fasting insul(FINS),Leptin(LEP)were detected,and homeostasis model assessment-insulin resistance(HOMA-IR)was calculated.Results:Compared with normal group,the FBG,FINS,LEP level and HOMA-IR were significantly increased in model group(P<0.01).Compared with model group,FBG,FINS,LEP level and HOMA-IR were significantly decreased in metformin group,Shenqi pill high dose group,Shenqi pill low dose group(P<0.05,P<0.01).Conclusion:Jingui Shenqi pill can reduce LEP and HOMA-IR,increase insulin sensitivity in rats with type 2 diabetes.