| 慢性乙型肝炎及肝炎肝硬化患者sICAM-1水平临床观察 |
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| 引用本文： | 张艳兰,李群,周宁. 慢性乙型肝炎及肝炎肝硬化患者sICAM-1水平临床观察[J]. 湖北民族学院学报(医学版 ), 2010, 27(1): 24-26 |
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| 作者姓名： | 张艳兰 李群 周宁 |
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| 作者单位： | 潍坊医学院传染病学教研室,山东,潍坊,261042;潍坊医学院传染病学教研室,山东,潍坊,261042;潍坊医学院传染病学教研室,山东,潍坊,261042 |
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| 摘 要： | 目的探讨慢性乙型肝炎（简称慢性乙肝）、肝炎肝硬化患者血清中可溶性细胞间粘附分子-1（sICAM-1）的表达水平及其临床意义。方法采用酶联免疫吸附分析（ELISA）法,测定10例健康对照人群、41例门诊及病区就诊患者的sICAM-1血清含量,其中慢性乙肝30例,肝炎肝硬化11例。结果与正常对照组相比,慢性乙肝患者和肝炎肝硬化患者血清中sICAM-1含量均显著增加（P〈0．01）。结论sICAM-1水平可作为评价肝细胞损害程度及肝纤维化程度的指标之一,并可能在肝炎及肝硬化的发病机制中发挥重要作用。
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| 关 键 词： | 细胞间粘附分子-1 慢性乙肝 肝炎肝硬化 |
Clinical Study on sICAM-1 Level in the Serum of Chronic Hepatitis B and Liver Cirrhosis after Hepatitis |
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| ZHANG Yan-lan,LI Qun,ZHOU Ning. Clinical Study on sICAM-1 Level in the Serum of Chronic Hepatitis B and Liver Cirrhosis after Hepatitis[J]. Journal of Hubei Institute For Nationalities(Medical Edition), 2010, 27(1): 24-26 |
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| Authors: | ZHANG Yan-lan LI Qun ZHOU Ning |
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| Affiliation: | ( Department of Epidemiology, Weifang Medical College, Weifang 261042, China ) |
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| Abstract: | Objective To explore the serum slCAM-1 level in chronic hepatitis B and liver cirrhosis after hepatitis and its clinical significance. Methods The serum sICAM-1 of 10 healthy persons as control and 41 patients was detected by enzyme- linked immunosorbent assay （ELISA）. Resets The level of slCAM-1 in 30 CH and 11 LC was significantly higher than healthy persons as control（P〈0. 01）. Conclusions The serum sICAM-1 level of patents with CH and LC is useful for the determination of the severity of liver disease and fibrosisi, sICAM-1 may play an important role in the the study of pathogenesis of liver diseae. |
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| Keywords: | sICAM-1 chronic hepatitis B liver cirrhosis |
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