| 18F-FDG PET/CT在胆道系统恶性肿瘤中的应用 |
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| 引用本文： | 张安南,张彦彦,张卫方,张燕燕,祝安惠.18F-FDG PET/CT在胆道系统恶性肿瘤中的应用[J].中国介入影像与治疗学,2019,16(3):154-157. |
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| 作者姓名： | 张安南 张彦彦 张卫方 张燕燕 祝安惠 |
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| 作者单位： | 北京大学第三医院核医学科 |
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| 基金项目： | 2016年国家科技部数字化诊疗装备研究试点专项（2016YFC0104005）。 |
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| 摘 要： | 目的探讨~(18)F-FDG PET/CT诊断胆道系统恶性肿瘤的价值。方法回顾性分析34例临床疑似胆道恶性肿瘤患者的PET/CT影像资料,均获得术后病理结果,其中12例经手术切除淋巴结或淋巴结穿刺活检对18枚淋巴结获得病理诊断;与病理结果对照,计算PET/CT对胆道恶性病变原发灶、淋巴结转移的灵敏度、特异度、阳性预测值、阴性预测值及准确率。结果 34例中,31例为恶性病变,3例为良性病变。PET/CT诊断胆道恶性肿瘤原发灶的灵敏度100%(31/31),特异度66.67%(2/3),阳性预测值96.88%(31/32),阴性预测值100%(2/2),准确率97.06%(33/34)。胆道恶性病变原发灶最大标准摄取值(SUV_(max))为8.42±4.27;3例胆道良性疾病SUV_(max)分别为12.90、2.00及1.90。共18枚淋巴结获得病理结果,包括转移性淋巴结13枚,良性增生5枚。PET/CT诊断淋巴结转移的灵敏度76.92%(10/13),特异度60.00%(3/5),阳性预测值83.33%(10/12),阴性预测值50.00%(3/6),准确率72.22%(13/18)。结论 PET/CT对胆道系统恶性肿瘤的诊断具有重要价值。
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| 关 键 词： | 胆道肿瘤 恶性 正电子发射体层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 |
| 收稿时间： | 2018/9/4 0:00:00 |
| 修稿时间： | 2018/12/11 0:00:00 |
Application of 18F-FDG PET/CT for the malignant tumors in biliary system |
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| ZHANG Annan,ZHANG Yanyan,ZHANG Weifang,ZHANG Yanyan and ZHU Anhui.Application of 18F-FDG PET/CT for the malignant tumors in biliary system[J].Chinese Journal of Interventional Imaging and Therapy,2019,16(3):154-157. |
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| Authors: | ZHANG Annan ZHANG Yanyan ZHANG Weifang ZHANG Yanyan and ZHU Anhui |
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| Institution: | Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China,Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China,Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China,Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China and Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China |
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| Abstract: | Objective To observe the value of 18F-FDG PET/CT in diagnosis of malignant tumors in biliary system. Methods A retrospective study of 18F-FDG PET/CT imaging feature was performed on 34 patients with clinical suspicion of biliary system malignancy. Pathological results of 18 lymph nodes were obtained in 12 patients after surgical operation or needle biopsy. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 18F-FDG PET/CT for detecting primary focus of malignant tumor and lymph node metastasis were obtained. Lymph nodes in 12 patients were examined by surgical or biopsy pathology. Results In 34 patients, there were 31 with malignant lesions and 3 with benign lesions. The sensitivity, specificity, PPV, NPV and accuracy of 18F-FDG PET/CT for detecting primary focus was 100% (31/31), 66.67% (2/3), 96.88% (31/32), 100% (2/2) and 97.06% (33/34), respectively. The maximum standardized uptake value (SUVmax) of primary focus of malignant tumors was 8.42±4.27, while of 3 cases with benign lesions was 12.90, 2.00 and 1.90, respectively. Pathological results were obtained in 18 lymph nodes, including 13 benign nodes and 5 malignant nodes. The sensitivity, specificity, PPV, NPV and accuracy of 18F-FDG PET/CT for diagnosing lymph node metastasis was 76.92% (10/13), 60.00% (3/5), 83.33% (10/12), 50.00% (3/6) and 72.22% (13/18), respectively. Conclusion PET/CT has important value in diagnosis of malignant tumors in biliary system. |
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| Keywords: | biliary tract neoplasms malignant positron-emission tomography tomography X-ray computed fluorodeoxyglucose F 18 |
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