| 不同机械指数诊断超声联合微泡对裸鼠胰腺癌移植瘤化疗的影响 |
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| 引用本文： | 冯爽,乔伟,益磋,朱琼,李佩倞,刘政.不同机械指数诊断超声联合微泡对裸鼠胰腺癌移植瘤化疗的影响[J].中国介入影像与治疗学,2019,16(2):107-111. |
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| 作者姓名： | 冯爽 乔伟 益磋 朱琼 李佩倞 刘政 |
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| 作者单位： | 陆军军医大学第二附属医院超声科 |
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| 基金项目： | 国家重点研发计划数字诊疗装备研发重点专项（2017YFC0107300）。 |
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| 摘 要： | 目的探讨不同机械指数(MI)诊断超声联合微泡对裸鼠人胰腺癌荷瘤模型肿瘤局部血流及化疗药物浓度的影响。方法经裸鼠双侧后腿注射肿瘤细胞,建立裸鼠人胰腺癌荷瘤模型33只,随机分为A、B、C组,行超声造影、化疗药物注射及超声辐照/假照。随机选取荷瘤裸鼠一侧后腿为治疗侧(超声辐照),另一侧为对照侧(超声假照)。辐照/假照前后均行超声造影,获得时间-强度曲线,峰值强度(PI)及AUC。于超声辐照/假照前经尾静脉注射阿霉素(DOX),并于超声辐照/假照过程中实时推注微泡;A、B、C组治疗侧超声辐照的MI分别为0.3、0.7、1.1。超声辐照/假照后,行DOX药物浓度检测及组织病理检查。并于超声辐照/假照前,测定不同MI对应的峰值负压范围。结果 A组治疗侧DOX药物浓度明显高于对照侧(1.45±0.53)μg/g vs(1.07±0.46)μg/g;t=-5.163,P=0.001]。B组及C组中,治疗侧与对照侧药物浓度差异均无统计学意义(Z=-0.297、-0.357,P=0.766、0.721)。超声造影定量分析显示,除B组对照侧PI、B组及C组对照侧AUC外,超声辐照/假照后各组中治疗侧及对照侧均较超声辐照/假照前PI均升高、AUC均增大(P均0.05)。各组对照侧与治疗侧肿瘤组织病理表现相似,未见明显出血及细胞肿胀。MI为0.3(A组)、0.7(B组)、1.1(C组)时,对应的实测峰值负压范围分别为0.81～0.83MPa、0.96～1.32 MPa和2.29～2.53 MPa。结论 MI为0.3的诊断超声联合微泡可增强肿瘤局部血流灌注,促进人胰腺癌荷瘤裸鼠肿瘤局部化疗药物释放。
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| 关 键 词： | 胰腺肿瘤 药物治疗 超声检查 微泡 小鼠 模型 动物 |
| 收稿时间： | 2018/9/29 0:00:00 |
| 修稿时间： | 2018/12/28 0:00:00 |
Impact of diagnostic ultrasound with different mechanical index enhanced by microbubbles on chemotherapy of nude mice bearing pancreatic tumor |
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| FENG Shuang,QIAO Wei,YI Cuo,ZHU Qiong,LI Peijing and LIU Zheng.Impact of diagnostic ultrasound with different mechanical index enhanced by microbubbles on chemotherapy of nude mice bearing pancreatic tumor[J].Chinese Journal of Interventional Imaging and Therapy,2019,16(2):107-111. |
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| Authors: | FENG Shuang QIAO Wei YI Cuo ZHU Qiong LI Peijing and LIU Zheng |
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| Institution: | Department of Ultrasound, the Second Affiliated Hospital ofArmy Medical University, Chongqing 400037, China,Department of Ultrasound, the Second Affiliated Hospital ofArmy Medical University, Chongqing 400037, China,Department of Ultrasound, the Second Affiliated Hospital ofArmy Medical University, Chongqing 400037, China,Department of Ultrasound, the Second Affiliated Hospital ofArmy Medical University, Chongqing 400037, China,Department of Ultrasound, the Second Affiliated Hospital ofArmy Medical University, Chongqing 400037, China and Department of Ultrasound, the Second Affiliated Hospital ofArmy Medical University, Chongqing 400037, China |
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| Abstract: | |
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| Keywords: | pancreatic neoplasms drug therapy ultrasonography microbubbles mice models animal |
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