Cerebrovascular lesions and livedo reticularis (Sneddon's syndrome) — a progressive cerebrovascular disorder? |
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Authors: | E. Rumpl J. Neuhofer A. Pallua J. Willeit G. Vogl G. Stampfel Th. Platz |
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Affiliation: | (1) Department of Neurology, University of Innsbruck, Austria;(2) Department of Dermatology, University of Innsbruck, Austria;(3) Department of Radiology, University of Innsbruck, Austria;(4) Department of Psychiatry, University of Innsbruck, Austria;(5) Neurologische Universitätsklinik, Anichstrasse 35, A-6020 Innsbruck, Austria |
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Abstract: | Summary Four cases are described in which livedo reticularis was associated with repeated cerebrovascular accidents, which eventually resulted in severe disability in two cases. Patients with severe disability had a history of many years, whereas two patients with little or moderate residual disability had a follow-up of 3 years each. CT scan revealed multifocal cerebral infarctions and cortical atrophy in all cases. Repeated cerebral angiograms, done in three cases, showed no signs of a vascular disease. There were no parameters that pointed to active immunological or inflammatory disorder. Neither clinical evidence of heart or large vessel disease was found. Observations suggest that a so-far unknown progressive cerebral vessel disease associated with livedo is the cause of a steady increase in multiple small cerebral infarctions. Because of the progressive character of the disease the search for effective therapy is needed. |
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Keywords: | Cerebrovascular lesions Livedo reticularis Progressive multifocal cerebral infarctions |
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