| 心肌Na^＋，K^＋-ATP酶在抑郁症时的活性及mRNA表达 |
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| 引用本文： | 李素琴,马欣欣,李晓晶,卢振敏,师贵文,刘玉欣,董彬,刘杰,胡景荣,孙东.心肌Na^＋，K^＋-ATP酶在抑郁症时的活性及mRNA表达[J].河北医药,2009,31(12):1422-1424. |
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| 作者姓名： | 李素琴 马欣欣 李晓晶 卢振敏 师贵文 刘玉欣 董彬 刘杰 胡景荣 孙东 |
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| 作者单位： | 1. 河北省疾病预防控制中心,石家庄市,050021
2. 河北省精神卫生中心 |
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| 摘 要： | 目的 探讨Na+,K+-ATP酶在抑郁症发病中的作用及其和单胺类神经递质之间的关系.方法 对SD大鼠进行慢性随机刺激建立抑郁症模型,检测大鼠心肌Na+,K+-ATP酶的活性及mRNA表达,海马组织及血液中去甲肾上腺素(NA)和5-羟色胺代谢物5-羟吲哚乙酸(5-HIAA)水平.结果 抑郁症大鼠心肌Na+,K+-ATP酶的转录水平下调(P＜0.01);酶的活性明显降低(P＜0.01);海马及血浆中的NA及5-HIAA水平显著下降(P＜0.01).结论 推测抑郁症时神经体液因素的变化可能是引起心肌细胞Na+,K+-ATP酶分子变化的原因之一,该酶在抑郁症的发病机制中有一定的生理和病理意义.
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| 关 键 词： | Na K -ATP酶 酶活性 mRNA表达 抑郁症 海马 神经递质 |
Myocardium Na~+,K~+-ATPase activity and its mRNA expression in depression in rats |
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| LI Suqin,MA Xinxin,LI Xiaojing,et al..Myocardium Na~+,K~+-ATPase activity and its mRNA expression in depression in rats[J].Hebei Medical Journal,2009,31(12):1422-1424. |
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| Authors: | LI Suqin MA Xinxin LI Xiaojing |
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| Institution: | LI Suqin,MA Xinxin,LI Xiaojing,et al.The Hebei Center for Disease Control , Prevention,Shijiazhuang 050021,China |
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| Abstract: | Objective To investigate the effect of Na~+,K~+-ATPase in depression and the relationship between Na~+,K~+-ATPase and monoamine neurotransmitters in rats.Methods The depression models of SD rats were established by chronic stimulation randomly for 21 days.The mRNA expression of myocardium Na~+,K~+-ATPase,the enzyme activity,norepinephrine(NA) and 5-hydroxyindoleacetic acid(5-HIAA,the metabolic product of serotonin)that participated in the regulation of affection,sleeping and memory,were detected.Results The... |
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| Keywords: | Na~+ K~+-ATPase enzyme activity mRNA expression depression hippocampus neurotransmitter |
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