Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice |
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| Authors: | Ando Masaru Yoshimatsu Tetsuyuki Ko Chiew Converse Paul J Bishai William R |
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| Institution: | Department of Medicine, Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, Maryland 21231-1001, USA. |
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| Abstract: | The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs. |
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