多形红斑45例临床分析

目的加强临床医生对多形红斑(EM)的认识,提高其治愈率。方法回顾性分析45例多形红斑患者的临床症状及实验室检查资料。结果45例均有EM典型临床表现,男∶女发病比为1∶1.5,平均年龄35.74±22.03岁。轻症EM37(82.22%)例,重症EM8(17.78%)例。其中17例皮损组织病理示基底细胞液化变性空泡改变,真皮浅层淋巴细胞浸润为主。结论EM是一个病谱病,临床上具有特征性,去除病因,及时控制感染,重症EM早期应用足量、短程糖皮质激素可提高治愈率。

Clinical Analysis of Patients with Erytherma Multiforma

Objective To strengthen the clinicians'understanding of EM. Meanwhile, to improve the cure rate of EM. Methods Clinical and lab data of 45 patients with erytherma multiforma were investigated retrospectively. Results All patients had typical clinical symptoms of EM,the ratio of male to female was 1∶1.5, the average age of onset was (35.74±22.03) years. Among 45 patients, there were 37 cases(82.22%) with erythema minor, 8 cases(17.78%) with erythema major. Biopsies of 17 cases showed keratinocyte necrosis in epidermis and basal vacuolization. The perivascular lymphocytic infiltration was found in the upper dermis. Conclusion EM was a spectrum of diseases with clinical characteristics. Removing cause of disease ,controling infection, and short-term of using corticosteroids showed promising rate of cure.