EGFR蛋白在人胃癌组织中的表达及其临床价值

目的研究表皮生长因子受体蛋白（EGFR）在胃癌中的表达及其与各临床病理特征之间的关系，回顾性分析EGFR蛋白表达与胃癌患者生存期的关系，探讨其成为胃癌预后指标和分子靶向治疗靶点的可行性。方法应用免疫组织化学方法检测具有随访资料的103例胃癌标本中EGFR蛋白的表达，并将检测结果与临床病理特征进行综合分析。结果0103例胃癌组织中EGFR蛋白的阳性表达率为42．7％（44／103），在胃正常组织中无表达；②EGFR蛋白表达与患者的性别、年龄、肿瘤大小、部位、分化程度均无相关性（P〉0．05），而与肿瘤的浸润深度、病理分期、淋巴结转移、远处转移相关（P〈0．05）；③EGFR蛋白表达阳性患者中位生存时间为11．0个月，表达阴性患者中位生存时间为65．2个月，阳性表达患者与阴性表达患者生存时间差异有统计学意义（P〈00．05）。结论OEGFR与胃癌的浸润、转移及预后密切相关，可作为判断胃癌生物学行为和预后的重要参考指标；②EGFR在胃癌组织中的阳性表达率较高，为IMC—C225、ZD1839、OSI-774等分子靶向治疗药物在胃癌的应用提供了理论依据。

Expression of EGFR Protein in Human Gastric Cancer and Its Clinical Value

Objective 　To investigate the expression of EGFR in gastric cancer and its relationship with clinical pathologic characters , analyze the relationship between EGFR expression and survival time of gastric cancer ,and discuss the feasibility of EGFR as prognostic markers and molecular target .Methods 　The expression of EGFR in gastric cancer was studied by immunohistochemical technique with its relation to follow2up data. We analyzed its detect outcome with clinical pathologic characters. Results 　①The 44 of 103 gastric cancer specimens (42. 7 %) were positive for EGFR ,and the expression of EGFR was not found in gastric normal tissue ; ②Their expression was not correlated with sex ,age ,size and site of tumor and degree of differentiation ( P > 0. 05) . The positive expression rates of EGFR was related to the depth of invasion ,clinical stage ,lymph node and distant metastasis of gastric cancer patients ( P < 0. 05) ; ③Median survival time of patients with EGFR positive is 11. 0 months. Median survival time of patient s with EGFR negative is 65. 2 months. There is statistical significe be2 tween median survival period of patients with EGFR positive and negative ( P < 0. 05) . Conclusion 　①The ex2 pression of EGFR was closely related to invasion ,metastasis and prognosis of gastric cancer , and it could be used to evaluate the biological behaviors and prognosis of gastric cancer. ②High positive rate of EGFR expression in gastric cancer ,provide a theoretical basis for application of molecular targeted drugs ,such as IMC2C225 ,ZD1839 and OSI2774.