| 金纳多对大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 赵海山,符静. 金纳多对大鼠心肌缺血再灌注损伤的保护作用[J]. 实用药物与临床, 2005, 8(4): 9-11 |
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| 作者姓名： | 赵海山 符静 |
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| 作者单位： | 1. 中国医科大学基础医学院药理教研室,沈阳,110001
2. 九三三○七部队医院,沈阳,110141 |
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| 摘 要： | 目的观察金纳多对心肌缺血再灌注损伤的保护作用。方法采用在体大鼠结扎冠状动脉前降支10min后,松扎再灌注30min造成心肌缺血再灌注模型,计算心肌梗死范围(MIS),测定血清磷酸肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量,观察心律失常发生情况。结果金纳多对心肌缺血10min再灌注损伤30min大鼠,可明显缩小MIS,降低血清CK、LDH活性和MDA含量,提高SOD活性,降低心律失常的发生率。结论金纳多对大鼠心肌缺血再灌注损伤具有保护作用。
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| 关 键 词： | 金纳多 心肌缺血再灌注损伤 自由基 血清酶 |
| 文章编号： | 1673-0070（2005）04-0009-03 |
| 收稿时间： | 2005-02-12 |
| 修稿时间： | 2005-02-12 |
Protective effect of Ginaton on myocardial ischemia-reperfusion injury in rats |
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| ZHAO Hai-shan,Fu Jing. Protective effect of Ginaton on myocardial ischemia-reperfusion injury in rats[J]. Practical Pharmacy and Clinical Remedies, 2005, 8(4): 9-11 |
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| Authors: | ZHAO Hai-shan Fu Jing |
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| Abstract: | ObjectiveTo investigate the influence of Ginaton on myocardial ischemia reperfusion injury in rat.MethodsThe myocardial ischemia-reperfusion model was induced by 10 min left anterior descending coronary occulusion and 30 min reperfusion in rats.The changes of myocardial infarct size(MIS),the serum creatine phosphokinase(CK),lactate lactate dehydrogenase(LDH),superoxide dismutase(SOD) activity,malondial dehyodebis(MDA) and occurrence ofarrhymia were investigated.ResultsIn rats treated by Ginaton,the MIS was significantly reduced,the serum CK and LDH activity declined,the serum SOD activity was increased markedly,the incidence of arrhymia declined.ConclusionConclusion Ginaton has protective effect on myocardial ischemia-reperfusion injury. |
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| Keywords: | Ginaton myocardial ischemia-reperfusion injury free radicals serum enzyme |
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