Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance |
| |
Authors: | Shigeru Saito Arihiro Shiozaki Yasushi Sasaki Akitoshi Nakashima Tomoko Shima Mika Ito |
| |
Affiliation: | (1) Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan |
| |
Abstract: | In the early pregnancy decidua, lymphocytes express some activation markers on their surface, suggesting that maternal lymphocytes are activated and recognize the semiallograftic fetus. Therefore, the immunoregulation system must work to prevent fetus rejection. Recent data showed that parts of the immunoregulation system such as CD4+CD25+ regulatory T (Treg) cells, Th3 cells, Tr1 cells, regulatory NK cells, and a tryptophan-catabolizing enzyme, indolamine 2,3 deoxygenase, play very important roles in the maintenance of pregnancy. Not only Treg cells but also regulatory NK cells may inhibit maternal T cell or NK cell fetal attack. |
| |
Keywords: | Pregnancy Regulatory T cell Regulatory NK cell Th3 cell Tr1 cell |
本文献已被 PubMed SpringerLink 等数据库收录! |
|