熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗肝硬化黄疸的疗效观察

目的观察熊去氧胆酸胶囊（优思弗）联合丁二磺酸腺苷蛋氨酸（思美泰）治疗肝硬化黄疸的疗效。方法肝硬化黄疽患者共46例，治疗组（23例）用熊去氧胆酸胶囊UDCA13．15mg/（kg·d），口服，Bid或Tid]联合丁二磺酸腺苷蛋氨酸（思美泰1000mg／d，静脉滴注）治疗，不使用甘草酸制剂等保肝药；对照组应用丁二磺酸腺苷蛋氨酸，其余药物基本相同。疗程2周，观察临床症状、肝功能的变化。结果经治疗后两组患者临床症状均有明显改善，肝功能指标均有好转，治疗组TBi1下降更明显（P〈0．05）。结论熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗肝硬化黄疸效果更好。

Observation on therapeutic effect of combined therapy of ursodeoxycholic acid capsules and ademetionine in patients with jaundice from cirrhosis

Objective To observe the therapeutic effect of combined therapy of ursodeoxycholic acid eapsules（ursofalk） and ademetionine（transmetil） in patients with jaundice from cirrhosis. Methods Forty six patients of jaundice from cirrhosis were randomly divided into treatment group（n=23） and control group（n=23）. Liver protection and supportive treatments were not given for the two groups. Ursodeoxycholic acid capsules10-15mg/（kg ~ d）, two or three times a day,for oral use] and ademetionine（Transmetil 1000mg/d intravenous drip） were given for the treatment group; the same treatments were given to the control group except ursodeoxycholic acid capsules.The treatment duration was 2 weeks in both groups.The liver function（TBIL,TBA,ALT and AST）, clinical symptom and physical sign were compared before and after being treated. Results After being treated, the liver function, clinical symptom and physical sign of treatment group got better.There was significant difference between two groups（P 〈 0.05）. Conclusion The combined treatment of ursodeoxycholic acid and ademetionine could obtain better curative effect.