结直肠癌基因治疗研究进展

【摘要】〓结直肠癌是常见的消化道恶性肿瘤,传统治疗以外科手术为主,辅以放、化疗,术后5年生存率仅为50%左右。近年来结直肠癌基因治疗备受人们青睐,且有许多研究成果成功运用于临床。目前对结直肠癌基因治的方法主要有原癌基因治疗、抑癌基因治疗、免疫基因治疗以及多基因联合治疗等。

Advance in gene-targeted therapy for colorectal cancer

Colorectal cancer is a common digestive tract cancer. Although the comprehensive treatments with primary surgery integrated with chemiotherapy or radiotherapy, the postoperative 5-year survival rate has not been improved evidently （about 50%）. In recent years, gene therapy for colorectal cancer has attracted much attention, nd many research results have been applied in Clinical. Currently, the main methods include proto-oncogenes therapy, tumor suppressor therapy, immunotherapy, complex gene therapy and so on.