p53,p21表达与直肠癌放疗敏感性的关系

目的：寻找直肠癌放疗敏感性与抑癌基因ｐ５３和ｐ２１的关系。方法：应用ＡＢＣ免疫组织化学方法检测６５例直肠癌口才放疗前肿瘤组织ｐ５３和ｐ２１的表达，并与放疗后肿瘤组织病理学变化进行比较。其中男性４４例，女性２１例，平均年龄５４．３岁。在６５例肿瘤中，高分化腺癌３４例，中分化腺癌１８例，粘液腺癌６例，低分化腺癌７例。依据术后切除标本分类，ＤｕｋｅｓＡ５例，ＤｕｋｅｓＢ３８例，ＤｕｋｅｓＣ１７例，Ｄｕｋ

Relationship between p53, p21 expression and radiosensitivity in rectal carcinoma

Objective:To study the relationship between p53, p21 expression and radiosensitivity in rectal carcinoma. Methods: p53 and p21 expression in formalin fixed, paraffin embedded, preradiation biopsy samples from 65 patients with rectal carcinoma were analyzed immunohistochemically and their relationship with tumor radiosensitivity were evaluated. Results: p53 and p21 expression were 54.3% and 29.8% respectively. Significant histopathological effect was observed in 35.5% of the tumors. There was a significant inverse expression between p53 and p21. Most of the p53(+) and/or p21(-) tumors were radioresistant while the majority of p53(-) and/or p21(+) were radiosensitive. Radiosensitive tumor decreased more significantly (47.4%) in size than radioresistant ones (22.4%). Conclusion: p53 and p21 may play important role in determing tumor radiosensitivity in rectal carcinomas.