| ~(125)I尖吻蝮蛇毒凝血样酶在兔体内的药物动力学 |
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| 引用本文： | 周仲达,蒋珠芬,杨士友,黄雨初,徐洵,张敬礼,邱宽生. ~(125)I尖吻蝮蛇毒凝血样酶在兔体内的药物动力学[J]. 中国药理学通报, 1988, 0(3) |
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| 作者姓名： | 周仲达 蒋珠芬 杨士友 黄雨初 徐洵 张敬礼 邱宽生 |
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| 作者单位： | 安徽省药物研究所 合肥(周仲达，蒋珠芬，杨士友)，中国科学技术大学 合肥(黄雨初，徐洵)，中国人民解放军第105医院 合肥(张敬礼)，中国人民解放军第105医院 合肥(邱宽生) |
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| 摘 要： | ~(125)Ⅰ标记尖吻蝮蛇毒凝血样酶,放化纯95.5％和比放射性188.7 MBq/mg。 兔iv ~(125)Ⅰ-TLE后,血放射性—时间曲线符合二室模型,算出药物动力学参数。组织分布以肾、胆、肝的放射性最高。
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| 关 键 词： | 蛇毒 凝血样酶 药物代谢动力学 |
PHARMACOKINETICS OF ~(125)I LABELLED SNAKE VENOM THROMBIN-LIKE ENZYME IN RABBITS |
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| Zhou Zhongda,Jiang Zhufeng , Yang Shiyou. PHARMACOKINETICS OF ~(125)I LABELLED SNAKE VENOM THROMBIN-LIKE ENZYME IN RABBITS[J]. Chinese Pharmacological Bulletin, 1988, 0(3) |
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| Authors: | Zhou Zhongda Jiang Zhufeng & Yang Shiyou |
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| Abstract: | The pharmacokinetics of thrombin-like enzyme ( TLE ) isolated from snake ( Agkistrodon acutus ) venom was reported .According to Gumaa's method, the TLE was labelled with isotope iodine(123I).The radio-chemical purity and specific activity of TLE were95.5% and 188.7 MBq/mg, respectively.After iv 125I-TLE in rabbits, the blood sample were drawn at various time and their radio-activity were determined. Data were fitted with 2 compartment open model. The pharmacokinetic parameters, such as T1/2, Vd, α, β, A, B, K12, K21, K10, AUC etc, were calculated. Distribution in kidneys, gall and liver were higher than other tissues. |
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| Keywords: | Snake venoms Thrombin-like enzymes Pharmacokinetics |
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