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Preemptive Surgery for Premalignant Foregut Lesions
Authors:Rohit R. Sharma  Mark J. London  Laura L. Magenta  Mitchell C. Posner  Kevin K. Roggin
Affiliation:(1) Department of Surgery, Section of General Surgery, University of Chicago Medical Center, Chicago, IL, USA;(2) Center for Clinical Cancer Genetics, University of Chicago Medical Center, Chicago, IL, USA;(3) Department of Surgery, Section of General Surgery, University of Chicago Pritzker School of Medicine, 5841 South Maryland Avenue, MC4052, Chicago, IL 60637, USA;
Abstract:

Introduction  

Preemptive surgery is the prophylactic removal of an organ at high risk for malignant transformation or the resection of a precancerous or “early” malignant neoplasm in an individual with a hereditary predisposition to cancer. Recent advances in molecular diagnostic techniques have improved our understanding of the biologic behavior of these conditions. Predictive testing is an emerging field that attempts to assess the potential risk of cancer development in predisposed individuals. Despite substantial improvement in these forms of testing, all results are imperfect. This information often becomes an important tool that is used by healthcare providers to evaluate the risk–benefit ratio of various risk modifying strategies (i.e., intensive surveillance or preemptive surgery).
Keywords:
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