Mechanical testing and osteointegration of titanium implant with calcium phosphate bone cement and autograft alternatives |
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| Authors: | Lin Dan-Jae Ju Chien-Ping Huang Shu-Huei Tien Yin-Chun Yin Hsiang-Shu Chen Wen-Cheng Chern Lin Jiin-Huey |
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| Affiliation: | aDepartment of Dental Hygiene, China Medical University, Taichung 40402, Taiwan, ROC;bDepartment of Materials Science and Engineering, National Cheng-Kung University, Tainan, 701, Taiwan, ROC;cDepartment of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan, ROC;dDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan, ROC;eDepartment of Fiber and Composite Materials, Feng Chia University, 100, Wenhwa Rd., Seatwen, Taichung, 40724, Taiwan, ROC |
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| Abstract: | The purpose of this study was to evaluate the osteointegration of a titanium (Ti) implant with the calcium phosphate cement (CPC) and autograft prostheses by pull-out test and histological examination. Stems of sixty Ti cylinders were bilaterally inserted into femoral medullary canals in 30 rabbits at the 1st, 4th, 12th, 26th and 70th postoperative weeks. The bone autograft and CPC were filled into the pre-trimmed bone marrow cavity with a polymethyl methacrylate retarder in the distal end, and then a Ti cylinder was inserted into femurs. The CPC group was significantly (p<0.05) associated with a larger pull-out force at 4th (37%) and 12th (62%) weeks compared to the autograft group. The bone area and the bone-to-implant contact ratios of the CPC groups were significantly higher than that of the autograft groups at early healing stage. The histological exams suggest that the CPC enhanced the earlier bone formation around the implant at a period not longer than 12 weeks postoperation. We conclude that CPC graft has the higher ability to facilitate the osteointegration and stabilize the Ti implant at a relatively early stage than the autograft in vivo. |
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| Keywords: | Autograft Calcium phosphate bone cement Titanium implant Pull-out test Osteointegration |
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