术中即时扩张皮肤面积增加与压力和时间的量效关系

目的探讨术中即时扩张皮肤面积增加与压力、时间的量效关系。方法用6头小型猪，压力参数分别为15、20、25kPa，时间参数为60、90min，配对组成6个实验组，1个对照组，36个实验部位。在每只猪背部皮下均匀埋置100ml圆形扩张器6个，术中即时扩张皮肤，观察扩张皮肤各径线移位特点，计算面积变化。结果扩张区周边皮肤向中心蠕动和扩张器表面皮肤伸展同时存在。扩张皮肤面积扩大在一定范围内与压力、时间增加成正比，20kPa、60min组合增幅最大，此后增幅明显减少，并逐渐引发皮肤病理性改变。结论皮肤可在一定范围内通过术中即时扩张获得面积有效增加。

Correlation of pressure and time with surface area in immediate expansion of skin during operation

Objective To study the dose-effect relationships between the surface area of immediate expanding skin and the pressure or time in the operation. Methods Six piglets were used in the animal experiments. Six experimental animals and one control were selected according to the pressures of 15, 20 and 25 kPa and the duration of 60 and 90 minutes. Total thirty-six expanders were implanted into the subcutaneous tissues on the back of animals, six experimental sites in each piglet. The surface areas of expanding skin were measured and the statistical analyses were performed. Results At certain extent, the area of expanding skin was enlarged correspondingly with the expanding pressure and duration increasing. When the parameters exceeded the pressure of 20 kpa and the time of 60 minutes, the expansion would not be added markedly anymore, but the injury signs of skin were gradually appeared. Conclusion Skin can be enlarged by expanding in the operation, and the best parameters are the pressure of 20Kpa and duration of 60 minutes.