Dendritic cells: ultrastructural and immunophenotypical changes upon nb-UVB in vitiligo skin |
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Authors: | Francesca Prignano F Ricceri B Bianchi D Guasti V Bonciolini T Lotti N Pimpinelli |
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Institution: | (1) Division of Clinical, Preventive and Oncology Dermatology, Department of Critical Care Medicine and Surgery, University of Florence, P.za Indipendenza, 11, 50129 Florence, Italy;(2) Department of Human Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy |
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Abstract: | The role of dendritic cells in vitiligo is still unclear. Few studies have provided contradictory results about their quantitative
variation and no data exist concerning their immunophenotypical distribution in diseased skin. The purpose of our study was
to analyze the presence, the distribution, the immunophenotypical markers and the effects of nb-UVB therapy on dendritic cells
in non-lesional, perilesional, and lesional vitiligo skin. Punch-biopsies of 6 mm were taken from lesional, perilesional,
and non-lesional skin of 12 patients affected by non-segmental vitiligo, treated with nb-UVB. An immunohistochemical and an
ultrastructural analysis were performed. Immunohistochemical and ultrastructural analysis showed both quantitative and qualitative
modifications of Langerhans cells. Nb-UVB therapy, one of the most effective treatments for the disease, was able to reduce
the Langerhans cells number and to redistribute main dendritic subsets. This study underlines the importance of dendritic
cells, Langerhans cells in particular, in non-segmental vitiligo, in its pathogenesis and in its better therapeutical approach. |
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