丙型肝炎患者血清细胞因子水平与肝功能损伤的相关性探讨

目的：检测血清可溶性L-selectin（L-选择素）、sICAM-1（细胞粘附因子-1）、IL-6（白细胞介素-6）、IL-10（白细胞介素-10）、IL-18（白细胞介素-18）在丙型肝炎病毒感染造成肝功能损害过程中的作用。方法：应用酶联免疫吸附法（ELISA）对62例丙型肝炎患者进行了血清中L-selectia、sICAM-1、IL-6、IL-10、IL-18水平检测及相关的肝功能、生化指标进行相关分析，并与36例正常健康人作比较。结果：丙型肝炎患者血清L-selectin、sICAM-1、IL-6、IL-10、IL-18水平均非常显著地高于正常人组（P〈0．01），且与ALT（谷丙转氨酶）、TBIL（总胆红素）水平呈明显的正相关。结论：检测丙型肝炎患者血清中L-selectin、sI—CAM-1、IL-6、IL-10、1L-18水平在一定程度上反映了机体的免疫功能状态和肝细胞损伤的程度，具有临床应用价值。

Study on the Relationship Between the Serum Levels of Several Cytokines (L-selectin, sICAM-1, IL-6, IL-10 and IL-18) and the Severity of Liver Function Impairement in Patients with Virus C Type Hepatitis

Objective To study the role of several cytokines (L-selectin, soluble intercellular adhesion molecule-1 i.e. sICAM-1, IL-6, IL-10 and IL-18) in the pathogenesis of liver function injury in patients with C type hepatitis. Method Serum L-selectin, sICAM-1, IL-6, IL-10 and IL-18 levels were measured with ELISA in 62 patients with hepatitis C and 36 controls. The serum ALT and total bilirubin levels were also examined. Results The serum level of L-selectin, sICAM-1, IL-6, IL-10 and IL-18 levels in the hepatitis C patients were significantly higher than those in the controls (P<0.01). The levels of these cytokines were significantly positively correlated with those of ALT and total bilirubin. Conclusion Detection of the levels of these cytokines might reflect the immune status and severity of liver cell injury in patients with hepatitis C.