| 白细胞介素6诱导小鼠T细胞杂交瘤细胞c－fos基因表达 |
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| 引用本文： | 杨宝学,杨贵贞.白细胞介素6诱导小鼠T细胞杂交瘤细胞c－fos基因表达[J].免疫学杂志,1994(3). |
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| 作者姓名： | 杨宝学 杨贵贞 |
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| 作者单位： | 白求恩医科大学免疫学教研室 |
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| 摘 要： | 本文应用Ｎｏｒｔｈｅｒｎｂｌｏｔ和斑点杂交技术，观察了ｒＩＬ－６对ＩＬ－６依赖株小鼠Ｔ细胞杂交瘤细胞ＭＨ６０的ｃ－ｆｏｓ基因表达的诱导作用。结果表明：ｒＩＬ－６可明显诱导ＭＨ６０细胞ｃ－ｆｏｓ基因表达，具有剂量效应关系，且表达程度与ＩＬ－６刺激ＭＨ６０细胞增殖速率相平行，提示ＩＬ－６促肿瘤细胞分裂增殖效应是由活化ｃ－ｆｏｓ基因所介导的。
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| 关 键 词： | IL－6 癌基因 分子杂交 |
c-fos Gene Expression Induced by IL-6 in the Mouse T Cell Hybridoma |
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| Yang Baoxue,Yang
Guizhen.c-fos Gene Expression Induced by IL-6 in the Mouse T Cell Hybridoma[J].Immunological Journal,1994(3). |
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| Authors: | Yang Baoxue Yang
Guizhen |
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| Abstract: | The mouse T cell hybridoma MH60 is an IL-6 dependent
cell line. Through Northern blot and dot analy-sis,we obeerved that c-fos gene expression
induced by rIL-6 in MH60 cells. The results showed that IL-6 could inducedsignificantly the
expression of c-fos gene in MH60 cells.There was a correlation between the c-fos gene
expression leveland the proliferative rate of MH60 cells stimulated by IL-6. These data indicate
that IL-6 promotes the cells proliferationthrough activiting c-fos proto-oncogene. |
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| Keywords: | IL-6 Oncogene Molecular hybridization |
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