| 大鼠原位肝移植胆道外引流模型的建立 |
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| 引用本文： | 王振杰,何晓顺,陈规划,黄洁夫. 大鼠原位肝移植胆道外引流模型的建立[J]. 中华肝胆外科杂志, 2002, 8(11): 667-669 |
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| 作者姓名： | 王振杰 何晓顺 陈规划 黄洁夫 |
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| 作者单位： | 1. 233004,安徽省,蚌埠医学院附属医院外科
2. 510080,广州市,中山医科大学第一附属医院腹部器官移植中心 |
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| 基金项目： | 本课题受卫生部临床学科重点项目资助 (基金编号 39470 714 ) |
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| 摘 要： | 目的 探讨建立大鼠原位肝移植胆道外引流模型的方法，为研究肝移植胆汁细胞学及免疫学等指标变化提供实验手段。方法 根据Kamada和孙君泓报道的术式加以多项技术改进建立大鼠原位肝移植胆道外引流模型，胆道外引流管采用的是硬膜外导管。结果 52次定型手术中成功44次，成功率为84．6％。44只手术成功大鼠中，下一步实验处死前死亡4只，其余40只均存活至下一步实验。结论 该大鼠原位肝移植胆道外引流模型建立方法操作简单，成功率较高。
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| 关 键 词： | 大鼠 原位肝移植 胆道外引流 模型 |
| 修稿时间： | 2001-06-27 |
Establishment of model of orthotopic liver transplantation with biliary extra-drainage in rats |
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| WANG Zhenjie,HE Xiaoshun,CHEN Guihua,et al.. Establishment of model of orthotopic liver transplantation with biliary extra-drainage in rats[J]. Chinese Journal of Hepatobiliary Surgery, 2002, 8(11): 667-669 |
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| Authors: | WANG Zhenjie HE Xiaoshun CHEN Guihua et al. |
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| Affiliation: | WANG Zhenjie,HE Xiaoshun,CHEN Guihua,et al. The Abdominal Organ Transplantation Center,the First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,P. R. China |
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| Abstract: | ObjectiveTo establish the model of the orthotopic liver transplantation with biliary extra-drainage in rats in order to study cytological and immunological changes in bile after liver transplantation. MethodsThe model of orthotopic liver transplantation with biliary extra-drainage was established in rats using the methods reported by Kamada and Sun Junhong with some modifications. The catheter used for biliary extra-drainage is perdural catheter. ResultsThe transplantation was performed in 52 rats and 44 (84.6%) survived postoperatively. Amongst these 44 rats, 40 were alive until the next experiment and 4 died. ConclusionsThe method used in this study is feasible and of high rate of success. |
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| Keywords: | Liver transplantation Biliary extra-drainage Model |
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