Mortality after orthotopic liver transplantation |
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Authors: | M. J. H. Slooff I. J. Klompmaker J. Grond K. M. De Bruijn R. Verwer E. J. Hesselink E. B. Haagsma |
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Affiliation: | (1) Department of Surgery, Liver Transplant Group, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands;(2) Department of Internal Medicine, Subdivision of Hepatology, Liver Transplant Group, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands;(3) Department of Pathology Liver Transplant Group, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands;(4) Department of Anesthesiology, Liver Transplant Group, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands |
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Abstract: | An analysis was made of the causes of death in 22 of 50 patients receiving consecutive orthotopic liver transplants. A close look at the fatal course of these patients revealed three major patterns: surgical complications (27%), pathology of the hepatic artery anastomosis (23%), and cholestasis (32%). Technical factors were the major reasons for excessive peroperative blood loss, and not the coagulopathy accompanying the liver disease. The etiology of hepatic artery thrombosis is not known. It leads to irreversible damage of the graft, causing death due to acute hepatic failure or to cholangitis and sepsis. The only way to treat patients with this complication is retransplantation. Several factors can induce cholestasis. Retrospectively, it appears that this was mostly due to inappropriate immunosuppression, often a result of the difficult differential diagnosis between rejection and viral infection. Recognition of these three basic patterns should enable us to anticipate their subsequent complications. This may lead to a reduction in morbidity and mortality after liver transplantation. |
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Keywords: | Liver transplantation Blood loss Hepatic artery thrombosis Cholestasis Mortality |
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